Acquired Cleft Palate Associated with Febrile Illness

While congenital cleft palate is thought to be an interaction of hereditary and environmental factors, acquired (ACP) caused commonly by cocaine inhalation in western countries. Other causes include infective (Tb, tertiary syphilis); trauma; connective tissue disease (SLE, vasculitis Wagner’s granulomatosis; sarcoidosis idiopathic. An uneducated 45-year-old presented with febrile skin eruption which evolved into necrolysis gangrene. This occurred following the ingestion quinine sulphate 650 mg orally, tds, for seven days a remote village Sudan. was treated conservatively antibiotics steroids resulting healing fibrosis.